Glycation and health
- Dan Thull

- Mar 15
- 2 min read
Updated: Mar 23

Consuming meals high in advanced glycation end products (AGEs) and those that induce rapid spikes in blood sugar can lead to a cascade of detrimental effects throughout the body. Glycation, a process where sugars bind to proteins or fats, forms these AGEs, which accumulate over time and contribute to cellular damage and inflammation. These compounds impair the function of various tissues and organs, accelerating aging and increasing the risk of chronic diseases. The rapid rise in blood glucose from high-glycemic foods further exacerbates this process by providing ample sugar for glycation to occur. This combination creates a harmful cycle that undermines overall health.
Here are 15 common high glycemic index foods:
White Bread | Corn Flakes | Watermelon |
Bagels | Instant Oatmeal | Pineapple |
White Rice | Pretzels | Dates |
Potatoes (baked) | Rice Cakes | Pumpkin (canned) |
Sugary Cereals | Honey | Raisins |
The cumulative damage from high-glycemic meals and AGEs manifests in various ways.
Cardiovascular health suffers as AGEs stiffen arteries and promote plaque formation, increasing the risk of heart disease and stroke. Kidney function can decline, as AGEs damage the delicate filtration systems within the kidneys. Neurological effects include an elevated risk of neurodegenerative diseases like Alzheimer's due to AGE accumulation in brain tissues. Furthermore, skin elasticity diminishes, leading to premature aging and wrinkles, as collagen and elastin become glycated. The inflammatory response triggered by these foods can also worsen conditions like arthritis and contribute to insulin resistance, paving the way for type 2 diabetes.
Ultimately, a diet consistently high in glycemic index foods and AGEs creates a systemic burden that weakens the body's defenses and accelerates degenerative processes. By reducing consumption of such foods and focusing on a diet rich in whole grains, fiber, lean proteins, and healthy fats, individuals can mitigate these risks and support long-term health and vitality.
Incorporating plenty of vegetables, whole grains, some fruits - but not too many - and lean proteins can help minimize sugar intake and lower the formation of AGEs. By making these dietary changes, not only can you support your weight loss journey, but you can also enhance your overall health and well-being, making it easier to achieve your fitness goals.



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